24-Hour Urine Collection Instructions (Acidified, Frozen)

Laboratory Supplies Needed:

  • 1 transport cooler (to be frozen beforehand)
  • 1 urine collection container with a yellow cap
  • 2 transport containers
  • 1 polyethylene tray
  • 24-hour urine collection container
  • Acidifying additive – 10% HCl (Keep out of reach of children. Avoid skin and mucous membrane contact.)

Urine Collection Procedure:

  1. Place the transport cooler flat in the freezer to pre-freeze.
  2. Begin urine collection, e.g., at 7:00 AM. Discard the first morning urine and record the starting time.
  3. Collect all urine over the next 24 hours, including the next day’s 7:00 AM sample, in the special 24-hour collection container. During collection, store the container in the refrigerator (2–8°C).
  4. Before adding the first urine sample, pour 10 mL of 10% HCl into the special container to acidify the urine.
  5. After the 24-hour period is complete, record the total urine volume collected.

Preparation for Transport to the Laboratory:

  1. Remove the 24-hour container from the refrigerator and shake it gently.
  2. Using the yellow-capped collection container, take 10 mL of urine twice (i.e., two 10 mL samples), and pour them into the two transport containers (10 mL each). Close the lids tightly.
  3. If the samples are being transported to the lab immediately, place both containers with urine in the pre-frozen transport cooler and deliver them to the lab.
  4. If the delivery to the lab is delayed more than 30 minutes, place the containers on a polyethylene tray and freeze them. Just before transport, move the frozen urine containers into the transport cooler and bring them to the lab.

Note:

  • The patient should consume approximately 1.5–2 liters of fluid during the collection period.
  • If the total urine volume exceeds 1 liter, add 10 mL of the acidifying agent for every additional liter.

 

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