As of September 1, 2024, the reference intervals (normal ranges) for key blood test parameters for both pediatric and adult patients at the “Mrcheveli” laboratory have been updated.
At “Mrcheveli,” the revision of reference intervals is a systematic and ongoing process. These updates are based on new population studies. The larger the control group and the number of examined samples, the more reliable the provided reference interval becomes.
Establishing pediatric reference intervals is a challenge worldwide, even in countries that conduct large-scale population studies. The primary reason for this is the rapid age-related physiological dynamics in children. A lack of reference ranges that accurately reflect these dynamics limits the utility of laboratory tests for children and can negatively impact their clinical management.
Our German colleagues have shared the results of their extensive research with us: PEDREF (Next-Generation Pediatric Reference Intervals) – This is a multicenter study with a database that integrates data from 15 German university medical centers and laboratory service providers, analyzing 20,000,000 samples from children aged 0 to 18 years.
The PEDREF study is led by scientists from the Department of Pediatrics at Erlangen University Hospital: Markus Metzler, Manfred Rauh, and Jakob Zierk (Head: Joachim Woelfle). The study was conducted with the support of the DGKL (German Society of Clinical Chemistry and Laboratory Medicine) working group.
Reference Literature for Pediatric Ranges:
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PEDREF Multicenter Study: “Next-generation reference intervals for pediatric hematology” by Jakob Zierk et al. The lower limit corresponds to the 2.5th percentile, and the upper limit to the 97.5th percentile.
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“Labor und Diagnose”, L. Thomas, 2020.
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Pediatric Reference Intervals; AACC; 7th edition; 2017.
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“Haematology reference intervals for established and novel parameters in healthy adults”, J. M. Pekelharing et al.
Reference Literature for Adult Ranges:
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“Labor und Diagnose”, L. Thomas, 2020.
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“Haematology reference intervals for established and novel parameters in healthy adults”, J. M. Pekelharing et al.; Diagnostic Perspectives, Vol 1, pp. 01–11.
Ia Nemsadze “Mrcheveli” Laboratory