The ROMA is used as a tool for risk assessment of epithelial ovarian cancer in patients undergoing surgery for an adnexal mass.

The combination of the tumor markers HE4 (Human Epididymis Protein 4) and CA 125 enables a more accurate prediction of a malignant disease than all other markers alone. An algorithm for estimating the risk of malignancy (Risk of Ovarian Malignancy Algorithm - ROMA) can be calculated from the HE4 and CA125 values.

In the chronological sequence of events in type 2 diabetes, the insulin resistance appears long before the hyperglycaemia becomes manifest. With the determination of the HOMA-IR a reliable detection of the insulin resistance is possible